Rare Oncology News

5 Facts you should know about

Activated PI3K delta syndrome (APDS)

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1

APDS, a Primary Immunodeficiency, was only characterized in 2013 - although it shares many features of other immune disorders, which means

APDS patients may have been previously misdiagnosed with other conditions

2

Signs and symptoms of APDS start in childhood,

and patients are vulnerable to repeat infections and immune dysregulation such as lymphadenopathy, splenomegaly, autoimmune cytopenias, and even lymphoma

3

Initially, patients with APDS may seek care from hematologists

because of swollen lymph nodes or low numbers of blood cells

4

Overproduction of B and T cells has been shown to appear as

swollen tonsils, lymphadenopathy, or a swollen spleen

5

Genetic testing is the only way to definitively diagnose APDS

and other primary immunodeficiencies that could lead to potentially fatal disorders like lymphoma