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Disease Profile


Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset





Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)



Hematohidrosis is a rare condition characterized by blood oozing from intact skin and mucosa. Signs and symptoms include sweating blood, crying bloody tears, bleeding from the nose, bleeding from the ears, or oozing blood from other skin surfaces. The episodes are usually self-limiting. In some cases, the fluid appears to be blood tinged, while others resemble frank blood. It can occur on any part of the body, but most commonly appears on the face (ear, nose, and eyes). The cause is unknown. The bleeding is due to the rupture of the very small blood vessels of the skin (dermal capillaries).[1] Some theories include increased vascular pressure leading to the passage of blood cells through the ducts of the sweat glands, inflammation of the vessels of the skin (vasculitis of dermal vessels), and intensified sympathetic activation.[2] Some cases are associated with systemic disease, bleeding disorders, menstruation, excessive exertion, high blood pressure, fear and intense emotional stress.[1][2][3][4] Treatment remains a challenge, and may include vitamin C, hemostatic drugs, anxiolytics, or antidepressants, and propranolol.[1][2][3] Resolution of symptoms may occur spontaneously.[1]

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hematohidrosis. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles


  1. Jafar A, & Ahmad A. Child Who Presented with Facial Hematohidrosis Compared with Published Cases. CaseReports in Dermatological Medicine. 781.. 2016; 2016:5095781. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808663/.
  2. Uber M & cols. Hematohidrosis: insights in the pathophysiology. Int J Dermatol. December, 2015; 54(12):e542-3. https://www.ncbi.nlm.nih.gov/pubmed/26227471.
  3. Khalid SR, Maqbool S, Raza N, Mukhtar T, Ikram A & Qureshi S. Ghost spell or hematohidrosis. J Coll Physicians Surg Pak. April, 2013; 23(4):293-4. https://www.ncbi.nlm.nih.gov/pubmed/23552544.
  4. Deshpande M, Indla V, Kumar V, Reddy IR. Child who presented with hematohidrosis (sweating blood) with oppositional defiant disorder. Indian J Psychiatry. 2014; 56:289-91. https://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2014;volume=56;issue=3;spage=289;epage=291;aulast=Deshpande.