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Disease Profile
Yellow nail syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
Adult
ICD-10
L60.5
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Lymphedema with yellow nails; YNS
Categories
Blood Diseases; Congenital and Genetic Diseases; Lung Diseases;
Summary
Yellow nail
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names |
Learn More:
HPO ID
|
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Bronchiectasis |
Permanent enlargement of the airways of the lungs
|
0002110 |
| Fingernail dysplasia |
Abnormal fingernail development
|
0100798 |
| Hypoplasia of lymphatic vessels |
Underdeveloped lymphatic vessels
|
0003759 |
| Lymphedema |
Swelling caused by excess lymph fluid under skin
|
0001004 |
| Toenail dysplasia |
Abnormal toenail development
|
0100797 |
| Yellow nails | 0011367 | |
| 30%-79% of people have these symptoms | ||
| Cough |
Coughing
|
0012735 |
| Dyspnea |
Trouble breathing
|
0002094 |
| Pleuritis |
Inflammation of tissues lining lungs and chest
|
0002102 |
| Recurrent respiratory infections |
Frequent respiratory infections
Multiple respiratory infections
respiratory infections, recurrent
Susceptibility to respiratory infections
[ more ] |
0002205 |
| Rhinitis |
Nasal inflammation
|
0012384 |
| Sinusitis |
Sinus inflammation
|
0000246 |
| 5%-29% of people have these symptoms | ||
| Biliary tract |
0100574 | |
| Generalized abnormality of skin |
Generalised abnormality of skin
|
0011354 |
|
Decreased immune function
|
0002721 | |
| Neoplasm of the lung |
Lung tumor
|
0100526 |
| Nephropathy | 0000112 | |
| Onycholysis |
Detachment of nail
|
0001806 |
| Pulmonary arterial |
Increased blood pressure in blood vessels of lungs
|
0002092 |
| Renal neoplasm |
Renal tumors
|
0009726 |
|
Cancer of connective tissue
Malignant connective tissue tumor
[ more ] |
0100242 | |
| Percent of people who have these symptoms is not available through HPO | ||
| Abnormality of the musculature |
Muscular abnormality
|
0003011 |
| 0000006 | ||
| Predominantly lower limb lymphedema | 0003550 | |
| Slow-growing nails | 0008383 | |
Cause
While most cases of yellow nail syndrome occur randomly, a few cases have run in families. Although this suggests that genetic factors may play a role in some cases, no known genetic factors have been identified.[2]
Rarely, yellow nail syndrome has occurred in people with
Diagnosis
Making a diagnosis for a genetic or rare disease can often be challenging. Healthcare professionals typically look at a person’s medical history, symptoms, physical exam, and laboratory test results in order to make a diagnosis. The following resources provide information relating to diagnosis and testing for this condition. If you have questions about getting a diagnosis, you should contact a healthcare professional.
Testing Resources
- Orphanet lists international laboratories offering diagnostic testing for this condition.
Treatment
In some cases, yellow nail syndrome goes away on its own or when an underlying, associated condition is treated.[1]
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
|
Conditions with similar signs and symptoms from Orphanet
|
|---|
|
The most important nail differential diagnoses include chronic paronychia, which shares absence of the cuticle and nail thickening and discoloration, and onychomycosis of the toenails, which produces thickening and onycholysis. Onychogryphosis and acquired pachyonychia should also be considered.
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
National Lymphedema Network (NLN)
411 Lafayette Street, 6th Floor
New York, NY 10003
Toll-free: +1646-722-7410
E-mail: [email protected]
Website: https://www.lymphnet.org
Organizations Providing General Support
-
American Lung Association
55 W. Wacker Drive, Suite 1150
Chicago, IL 60601
Toll-free: 1-800-548-8252 (1-800-LUNGUSA)
E-mail: [email protected]
Website: https://www.lung.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Yellow nail syndrome. Click on the link to view a sample search on this topic.
References
- Vignes S and Baran R. Yellow nail syndrome: a review. Orphanet J Rare Dis. February, 2017; 12:42:https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0594-4.
- Yellow Nail Syndrome. National Organization for Rare Disorders (NORD). 2015; https://rarediseases.org/rare-diseases/yellow-nail-syndrome/.
- Berglund F, Carlmark B. Titanium, Sinusitis, and the Yellow Nail Syndrome. Biol Trace Elem Res. October, 2011; 143(1):1-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176400/.
- Decker A, Daly D, Scher RK. Role of Titanium in the Development of Yellow Nail Syndrome. Skin Appendage Disord. March, 2015; 1(1):28-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857837/.
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